source : Korea Disease Control and Prevention Agency API_HealthInfo
- Damage to the pancreatic gland cells (exocrine cells of the pancreas) occurs due to various causes such as gallstones, drinking alcohol, metabolic disorders, drugs, and abdominal damage. Inflammatory disorders of the pancreas that can lead to organ failure
- Usually caused by alcohol or gallstones in the gallbladder or bile ducts
- The exact mechanism by which alcohol causes acute pancreatitis is still unknown. Gallstones obstruct the flow of pancreatic juice, causing acute pancreatitis.
- Ten to one or two will progress to severe pancreatitis
- In severe cases, the pancreas itself does not circulate, resulting in necrosis in which the pancreas tissue rots.
- 20% of patients with acute pancreatitis develop severe acute pancreatitis, and 36-50% of them show hypotension and shock due to systemic inflammatory response due to organ failure within the first few days, and multiple organ failure including kidney and lungs will result in death.
by the Ministry of Food and Drug Safety (2020.10)
Phase 2a Clinical trial completed
Indicationmoderately severe to severe
Number of patients36 people
Cohort 1: 20 subjects in the test group
Cohort 2: 16 patients in the placebo group
Dosing regimen2 weeks intervals / 3 times
1.0 X 106 cells/kg,
Day0, 1, 2
Designmulticenter, double-blind, placebo control
Modified Marshall Score at 7 days or CT Severity Index at 28 days from baseline