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SCM Life Science has obtained a U.S. patent for the composition of drugs that treat immune diseases by combining mesenchymal stem cells and controlled T cells.
News
2022-01-28
SCM Life Science (SCM Life Science, Kosdaq 298060, CEO Lee Byung-gun), a development company specializing in cell therapy, announced on the 21st that it has obtained a U.S. patent for pharmaceutical compositions that can be used to prevent and treat immune diseases by inducing the cmesenchymal stem cell and regulatory T cells.
The patented pharmaceutical composition is
mesenchymal stem cells over-expressed icosl (incible costimulatory ligand).
When an immune response occurs in the body, a protein called icosl is
overexpressed in mesenchymal stem cells. At the same time, the expression of
icos protein, a receptor that binds to icosl, increases on the surface of
regulated t cells that perform immunosuppressive functions in the body. Regulating
T cells perform the function of regulating the immune response of T cells,
which are representative immune cells in the body. Increased interaction
between mesenchymal stem cells and regulated T cells through the binding of
ICOSL and ICOS receptors promotes cytokine secretion called IL-10 from
regulated T cells, effectively regulating the immune response of abnormally
increased CD4+ T cells.
Mesenchymal stem cells overexpressed with
ICOSL in these mechanisms can be used to treat various inflammatory or
autoimmune diseases. This patent can be used to treat a variety of autoimmune
diseases, including ▲ rheumatoid arthritis ▲ circular alopecia ▲ colitis ▲
ulcerative colitis ▲ insulin-dependent childhood diabetes by pancreatic cell
antibodies ▲ psoriasis ▲ multiple sclerosis ▲ fibrous tissue ▲ lupus.
The patent has already been registered in
countries such as Korea, China, Japan, Australia, and Russia. The registration
of U.S. patents is significant in that it has become a technical and legal
basis for SCM Life Science' R&D in the U.S. and entry into the market.
SCM Life Science recently signed a license
agreement with Allive Biotechnology & Pharmaceuticals, a U.S. bio-venture,
for a treatment for pancreatic beta-cell diabetes derived from iPSC, and
invested in the development of muscle disease treatments using rare muscle
cells.
Through this U.S. patent registration, SCM
Life Science can secure core intellectual property rights for global
commercialization as a specialized cell therapy development company.